Overview | Understanding Coagulation | Assessment & Monitoring | Clinical Contexts | Treatment Strategies | Reversal of Anticoagulation & Antiplatelets | Guidelines & Evidence

Resources for Coagulation

Below, please find links to useful resources to learn more about various coagulation topics. The list includes clinical guidelines, society consensus statements, practice advisories, as well as landmark trials that have made an impact on our coagulation management of patients. This list will be updated regularly to keep you informed of the latest news and current evidence in coagulation.

Clinical Guidelines

1. 2021 STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management
2. 2025 Cardiac Surgical Bleeding, Transfusion, and Quality Metrics: Joint Consensus Statement by the Enhanced Recovery After Surgery Cardiac Society and Society for the Advancement of Patient Blood Management
3. 2019 Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients
4. 2020 American College of Cardiology Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants
5. 2023 European Guideline on Management of Major Bleeding and Coagulopathy Following Trauma: 6^th edition
6. 2022 Management of Severe Peri-operative Bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care
7. Thromboelastography and Rotational Thromboelastometry in Bleeding Patients with Coagulopathy: Practice Management Guideline from the Eastern Association for the Surgery of Trauma
8. Strategies to Prevent Blood Loss and Reduce Transfusion in Emergency General Surgery, World Society of Emergency Surgery – American Association for the Surgery of Trauma Consensus Paper
9. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations

Landmark Trials

1. FARES-II: Prothrombin complex concentrate vs fresh frozen plasma for coagulopathic bleeding in cardiac surgery: the FARES-II multicenter randomized clinical trial
2. WOMAN Trial: Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
3. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients
4. POISE-3 Trial: Tranexamic acid in patients undergoing noncardiac surgery
5. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays
6. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery