Summary [Remmers and Speer review some of the strategies used in the non-blood management of Jehovah’s Witness patients. They summarize Witness patients’ position on blood, blood components, blood derivatives and autologous blood options. They address, with support from the literature, approaches to managing bleeding and trauma and illustrate a proposed algorithm for the management of severe acute anemia. A brief synopsis of the surgical, anesthetic and pharmacological strategies is presented along with a table listing “oxygen therapeutics” in clinical trials.