Antifibrinolytic

A pharmaceutical agent that inhibits fibrinolysis (the splitting up or dissolution of blood clot). Coagulation and fibrinolysis are natural biologic functions in blood. By inhibiting fibrinolysis, coagulation is theoretically enhanced. By enhancing coagulation or minimizing the effects of excess fibrinolysis, surgical hemorrhage in the presence of fibrinolysis may be reduced. Examples include aprotinin (serine protease inhibitor) and epsilon aminocaproic acid, tranexamic acid (lysine analogs).